Neural tube defect recurrence after 'partial' vitamin supplementation.

Recurrent neural tube defects, risk factors and vitamins.

Data from our trial of periconceptional vitamin supplementation for the prevention of neural tube defects have been analysed to assess the influence of various factors on recurrence rates of neural tube defect. Our data suggest that the risk of recurrence of neural tube defect is influenced by the number of previous neural tube defects, area of residence, immediately prior miscarriage, and inte...

Recurrence of neural tube defect in a group of at risk women: a 10 year study of Pregnavite Forte F.

It is now more than a decade since Smithells et all first reported an apparent reduction in the recurrence rate in women at risk for a neural tube defect (NTD) when they were supplemented with Pregnavite Forte F around the time of conception. A multicentre study2 and a further report by Smithells et aP support this observation. We summarise the findings of our own 10 year study, which adds to t...

Periconceptional vitamin supplementation and the prevention of neural tube defects.

A comparison has been made of the effectiveness of periconceptional vitamin supplementation for the prevention of recurrence of neural tube defects (NTD) in south-east England and Northern Ireland. These areas represent the extremes of birth prevalence of NTD (low and high respectively) within the United Kingdom. Vitamin therapy resulted in a slightly less than two-fold reduction in the recurre...

Recurrence rates for neural tube defects and vitamin supplementation.

Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification.

OBJECTIVE Folic acid fortification has reduced neural tube defect prevalence by 50% to 70%. It is unlikely that fortification levels will be increased to reduce neural tube defect prevalence further. Therefore, it is important to identify other modifiable risk factors. Vitamin B(12) is metabolically related to folate; moreover, previous studies have found low B(12) status in mothers of children...